The cross border Bus Tufesa, The ADO Bus system, and the cross border Tica will take you from Salt Lake City To Panama City.  If you want to see many of the parks, cities, beaches, and ruin sites along the way, bus service is an ideal way to travel.  
Bus Travel Through Mexico Salt Lake City To Panama City,
Tufesa, ADO, Tica: Salt Lake City To Panama City
beaches, and ruin sites along the way, bus service is ideal .  
The following series of articles will detail the long haul, first class bus service that makes a luxury run through the US, Mexico, and
Central America possible.

Tufesa buses leave from 16 locations in California and four in Arizona as well as Salt Lake City and Las Vegas.  They make the border crossing and reach south to Guadalajara with
many stops along the Pacific coast.  Once in Mexico you will find that Mexico's Bus systems are a great way to see the country. They use dozens of hub cities to reach even the most distant ruin Site and colonial city for about 1 peso per mile. (.10 cents USD) The roads are a combination of modern high-speed toll roads (quota) and secondary roads.

Mexico second class bus lines are based in every city.  They use secondary roads.  The first class buses avoid the steep mountain roads wherever possible; the mountains are so steep that people get motion sickness on the twisting mountain roads

Mexico's first Class buses have plush seat for sleeping, leg rests, air conditioning, (bring a sweater) lavatories, seat belts, deeply reclining seats, and video movies. (Bring ear plugs for the back to back Cantinflas retrospectives.)

Mexico first class bus travel will reveal one of the best bus systems in the world.  Mexico’s long-haul Flecha Amarilla, ADO, Cristobal Colon, UNO,
Chihuahuenses, Tap, Omnibus, and other lines reach all of Mexico in luxury.  Several bus line cross the border.  Tufesa is one that serves Utah, Las Vegas, Nevada, and California with cross border buses.

You can take a Tufesa bus from
Tucson Arizona to Guadalajara, Mexico.
The Tufesa buses run from Salt Lake City, Utah to Guadalajara, Mexico. They come in from Phoenix several times a day.  The buses come in three a day and leave for Nogales and crosses the border bound for Guadalajara.

For those interested in touring all the way to
Central America by bus , you could go from Guadalajara on a Primera Plus bus to Mexico City’s Terminal Norte, and then an ADO bus to Tapachula, Chiapas and then a Tica Bus to Panama City, Panama.

David Rice bus South America Eight Months By Bus      for an account of David Rice's eight month bus trip from Missouri to Antarctica and back

You could travel the length of Mexico and visit few cities along the way.  From Mexico City reach Oaxaca via ADO first class bus service out of Mexico City’s Terminal Norte or TAPO.
From Oaxaca go south to Tapachula via ADO (OCC) and Find the Tica Bus terminal in the first class station.

Posted by
SoftSeatTraveler at 8:59 PM
See Sample Trip

More later:
See Page Two
Bus service covers the US, Canada, and Mexico and you can go all the way from north of the US Border through Salt Lake City Utah all the way to Panama City, Panama by bus.

Beyond Panama City Panama there are  there are no reliable roads south; you go by boat or plane
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