For independent travelers through Southern Mexico to Central America as far south as Panama City, there is a bus option that takes some of the anxiety out of finding the next bus. This system is called the Tica Bus for short and stands for Tansportes Internacionales Centroamericanos:

Make reservation via email and pay when arriving at the terminal.
The above mentioned trip leaves Mexico and goes through Guatemala to El Salvador where it stops for the night. It then goes to Managua and stops for the overnight. The bus then makes a day and overnight trip to Panama City, Panama.
Central America Bus Travel, The Tica Bus,   Luxury buses crossing the borders in Central America.
Central America Bus Travel, Tica Bus, Chiapas to Panama
The road south over central America end in Panama.  Beyond Panama south the roads become impassible during the rainy season.  The roads turn to dirt track and only a few 4wd vehicles make the passage through this break in the Panamerican Highway called the Darien Gap. Flight and boat passage is the only way to reach south America from Panama.
Bus service through Central America can be made simpler and safer by the Tica Bus.
The line runs a total of 38 air-conditioned buses that have reclining seats, restrooms, window curtains, TV and video.
Leave Tapachula at 7:00 am, arrive at Guatemala City at 12:00 noon.

Guatemala at 1:00 p.m, arrive at El Salvador approximately at 5:00 p.m

El Salvador at 5:00 a.m, arrive at Nicaragua approximately
at 5:00 p.m.

Nicaragua at 6:00 a.m, and 12:00 noon, arrive at Costa Rica approximately at 4:00 p.m. 5:00 p.m. and 9:00 p.m.

Leave Costa Rica at 10:00 p.m. on the same day and arrive at
Panama at 4 in the afternoon the following day.

Passengers can stop for extended stays in the terminal cities, the ticket is still honored, they must however make a reservation and reserve a seat to continue. Passengers pay additional for their hotel, and food. Passengers should also 0plan for paying customs and immigration fees, charges which averages $10 USD

Tica runs a total of 38 air-conditioned, 54-passenger buses that have reclining seats, restrooms, window curtains, TV and video.
Tica Bus Logo
Central America Bus Travel, Tica Bus, Chiapas to Panama offers cross-border bus service between Tapachula Chiapas Mexico and Panama City Panama.   See fares and schedule below
Central America Bus Travel, Tica Bus, Chiapas to Panama offers  a   2014, round trip ticket price of  $356 USD
Mexico to Panama Central America is $356. USD  Round trip, paid in US Dollars, travelers checks, or the currency of the country.  Credit cards accepted only for advanced, online sales.   See Link
Buy tickets for the Chiapas trip south through ADO Bus in OCC Bus terminal in Tapachula, Chiapas, Mexico.
Tica Bus Fares
Central America Bus
Tica Bus Schedule
Tica Bus Routes
Tica Bus, Central America
Tica Bus, Chiapas Panama
Central America Bus travel includes tica Bus from Tapachula, Chiapas to Panama City, Pamana.
See Link here for advanced Tica Bus Ticket buying info and email
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